There was no significant difference in the time to shunt failure between the entry sites (log-rank test, stratified by age < 6 months and ≥ 6 months p = 0.061). The median patient age was 1.3 months, and the most common etiologies of hydrocephalus were postintraventricular hemorrhage secondary to prematurity (32.7%), myelomeningocele (16.8%), and aqueductal stenosis (10.8%). For the primary analysis, there were 229 patients in the posterior group and 224 patients in the anterior group.
The adjudication committee, blinded to intervention, excluded 7 patients in each group for not meeting the study inclusion criteria.
The study randomized 467 pediatric patients at 14 tertiary care pediatric hospitals in North America from April 2015 to January 2019.
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